Endocrine Abstracts

Background: Inflammatory skin diseases such as psoriasis induce changes in the skin-secretome, which potentially lead to dysfunction of key metabolic tissues and increased risk of psoriasis co-morbidities, such as type 2 diabetes (T2D). However, the proteins and peptides that make up the skin-secretome remain poorly characterised. Proteomic analysis has identified vimentin, parathymosin, prothymosin-alpha, dermcidin, and desmin as potential skin-secretome factors, which may in...

The inflammatory skin disease psoriasis is an independent risk-factor for development of insulin resistance. However, the underlying mechanisms remain poorly elucidated. We used human and mouse models of psoriasis to investigate a potential endocrine role of the skin in regulating subcutaneous adipose tissue (sAT) and pancreatic islet function. Mice were administered a daily topical dose (75 mg) of imiquimod (IMQ), or Vaseline control, to a shaved dorsal region for 4 days. IPG...

Intracellular nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme in the NAD salvage pathway. Abnormally elevated NAMPT can promote autoimmune and inflammatory processes. Many of these processes are key to type 1 diabetes (T1D) pathogenesis. Whilst NAMPT has been examined in other inflammatory diseases, the role of NAMPT in T1D remains unclear. To investigate the role of NAMPT in T1D, we used small molecule NAMPT modulators to determine the role of abnor...